Epidermal nuclear staining: A distinct reaction pattern in connective tissue diseases

Epidermal nuclear staining: a distinct reaction pattern in connective tissue diseases.

Epidermal nuclear staining occurs as a result of anti-nuclear antibody (ANA) deposition in the nucleus of keratinocyte (‘In vivo ANA’). The frequency with which it occurs in various CTD’s varies between 2.6-9.8%.[2] The high prevalence in our study could be due to the smaller study sample. Four different patterns of ENS (viz. speckled, homogenous, nucleolar and rim) have been reported in the li...

Epidermal nuclear immunoglobulin deposits in some connective tissue diseases: correlation with ENA antibodies.

In-vivo nuclear deposits of IgG were demonstrated by direct immunofluorescence in epidermal cells of normal skin from 6 patients with serum antibodies to an RNase-sensitive extractable nuclear antigen (ENA). Addition of complement to the skin sections showed that C3 could bind to epidermal cells with IgG deposits. A skin biopsy from a patient with polymyositis and serum antibodies to ENA, but w...

Connective tissue diseases.

Undiagnosed connective tissue diseases

Among different subgroups of pulmonary arterial hypertension (PAH), those associated with connective tissue diseases (CTDs) have distinct hemodynamic and prognostic features; a correct etiologic diagnosis is thus mandatory.To estimate frequency and prognosis of previously undiagnosed CTDs in a suspect idiopathic (i) PAH cohort.Consecutive patients with PAH confirmed by right heart catheterizati...

Vistas in Connective Tissue Diseases

each excellent paper there is a discussion by the very distinguished members of the study group. The reviewer is, as might be surmised, in favor of disease-orientated research, believing that the application of basic science to clinical problems is the essence of modern medicine. He also believes that conferences such as this provide an opportunity for a valuable exchange of ideas. Unfortunatel...